Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort

Abstract Objective To evaluate the genetic effects of sex hormone traits on development mental in middle-aged adults. Methods The SNPs associated with were derived from a two-stage genome-wide association study (GWAS). Four selected current study, including hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. polygenic risk score (PRS) calculated individual-level genotype data United Kingdom (UK) Biobank cohort. We then used logistic linear regression models to assess associations between individual PRS frequency alcohol consumption, anxiety, intelligence so on. Finally, gene-environment-wide interaction (GEWIS) was performed detect novel candidate genes interacting fluid smoking consumption by PLINK2.0. Results observed positive SHBG (b = 0.0101, p 3.84 × 10 –11 ) males females. In addition, estradiol positively 0.0128, 1.96 –8 males. Moreover, − 0.0136, 5.74 –5 GEWIS identified one significant loci, Tenascin R (TNR) (rs34633780, 3.45 total for intelligence. Conclusion Our results support adults UK.